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Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)

Fiscal Year Awarded:

2019

Principal Investigator:

Sloan Devlin

Targeting neuro-immune signaling to treat bacterial infections

Fiscal Year Awarded:

2019

Principal Investigator:

Isaac Chiu

Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes

Fiscal Year Awarded:

2018

Principal Investigator:

David Knipe

Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation

Fiscal Year Awarded:

2018

Principal Investigator:

Michael Greenberg

Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD

Fiscal Year Awarded:

2018

Principal Investigator:

Junying Yuan

Identification of dengue virus inhibitors

Fiscal Year Awarded:

2018

Principal Investigator:

Priscilla Yang

Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance

Fiscal Year Awarded:

2017

Principal Investigator:

Priscilla Yang

Building better screens and identifying ligands for human MS4A proteins

Fiscal Year Awarded:

2017

Principal Investigator:

Sandeep Datta

Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors

Fiscal Year Awarded:

2017

Principal Investigator:

Marc Kirschner

Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation

Fiscal Year Awarded:

2017

Principal Investigator:

Michael Greenberg