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Fiscal Year Awarded Principal Investigator
Antibody-based therapeutics against Nipah virus
2023 Jonathan Abraham
Monoclonal antibody-based therapeutics for Argentine hemorrhagic fever
2020 Jonathan Abraham
Targeting apoptotic pathways for ALS, Alzheimer’s Disease and Parkinson’s Disease
2020 Bruce Bean
Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)
2019 Abigail Devlin
Development of synthetic analogs of a sleeve gastrectomy-induced metabolite as a novel therapy for type 2 diabetes and obesity
2020 Abigail Devlin
Small molecule modulators of bile acid metabolism to treat NAFLD/NASH
2022 Abigail Devlin
Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2017 Michael Greenberg
Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2018 Michael Greenberg
Next-generation AAV therapies for management of intractable chronic pain
2020 Michael Greenberg
Developing novel therapeutic approaches for CNS drug delivery by targeting a newly identified key regulator of the blood brain barrier
2020 Chenghua Gu
CNS drug delivery by identifying small molecule inhibitors of a newly identified key regulator of the blood brain barrier
2022 Chenghua Gu
Functional antibody screening with micro-capsules - proof of concept with anti-EGFR
2024 Allon Klein
Methods and applications of semi-permeable capsules with current application to high-throughput single cell multi-omics
2023 Allon Klein
Interleukin-17 as a novel erythropoiesis stimulating agent
2020 Allon Klein
Engineered proteins for treatment of pancreatitis
2020 Pamela Silver
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2020 Karen Adelman
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2021 Karen Adelman
Evaluating antisense oligos for therapeutic impact in liver fibrosis and hepatocellular carcinoma
2023 Karen Adelman
Development of a synthetic promoter pipeline for safe and efficient gene therapy
2024 George Church
Novel biologics for cancer therapy
2022 George Church
Multiplex editing the human genome
2020 George Church
A platform for transcriptome time-series in single cells with applications to hematopoietic stem cells
2022 Johan Paulsson
A high-throughput platform for the non-invasive intracellular delivery of molecules for therapeutic applications
2020 Johan Paulsson
Target validation and in vivo testing of a broad-spectrum antiviral
2020 Priscilla Yang
Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance
2017 Priscilla Yang
Identification of dengue virus inhibitors
2018 Priscilla Yang
Development of a new precision therapeutic for an important cancer target
2019 Stephen Blacklow
Agents modulating B cell activation through the CD81-CD19 co-receptor complex
2023 Stephen Blacklow
Targeting neuro-immune signaling to treat bacterial infections
2019 Isaac Chiu
Development of new antiviral compounds
2019 Donald Coen
Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness
2019 David Corey
Gene editing to treat hereditary deafness
2024 David Corey
Identifying novel therapeutic targets for treating pain and chronic itch
2021 David Ginty
Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders
2019 David Ginty
Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases
2019 Peter Park
A novel system for rational discovery of polycystic kidney disease therapeutics
2019 Adrian Salic
Development of an inexpensive at-home influenza kit and detection technology
2019 Michael Springer
Enzyme prospecting for better diagnostics
2022 Michael Springer
Development of an inexpensive at-home influenza kit and detection technology
2021 Michael Springer
Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD
2018 Junying Yuan
Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes
2018 David Knipe
Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors
2017 Marc Kirschner
Restoring cortical function and plasticity for the treatment of Alzheimer’s Disease
2017 Bernardo Sabatini
Building better screens and identifying ligands for human MS4A proteins
2017 Sandeep Datta
Small molecule drugs for advanced cancer with ecDNA amplicons
2022 Timothy Mitchison
A kinase inhibitor for malignant brain tumors
2023 Timothy Mitchison
Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury
2017 Timothy Mitchison
Design of novel protease inhibitors to enhance immune checkpoint blockade in cancer therapy
2024 Mark Namchuk
Development of novel AAV-mediated in vivo gene editing approaches to treat inherited collagen VI-related myopathies
2024 Amy Wagers
Gene therapy for the treatment of Wolfram Syndrome II
2022 Amy Wagers