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Fiscal Year Awarded
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Principal Investigator
Developing a ubiquitin-dependent proteasome activity reporter to screen for activators and inhibitors
2017
Marc Kirschner
Restoring cortical function and plasticity for the treatment of Alzheimer’s Disease
2017
Bernardo Sabatini
Assessment of targeted protein degradation as a strategy for potent antivirals with high barriers to resistance
2017
Priscilla Yang
Building better screens and identifying ligands for human MS4A proteins
2017
Sandeep Datta
Microtubule stabilizing drugs for neurodegenerative disease and spinal cord injury
2017
Timothy Mitchison
Developing therapeutics for treating Rett syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2017
Michael Greenberg
Developing therapeutics for treating Rett Syndrome by correcting neuronal long-gene misregulation – Lead compound optimization and in vivo validation
2018
Michael Greenberg
Identification of dengue virus inhibitors
2018
Priscilla Yang
Development of small molecule modulators of autophagy and ER stress as novel therapeutics for AD
2018
Junying Yuan
Developing CRISPR-Cas9 reagents for editing lytic and latent herpes simplex virus genomes
2018
David Knipe
Isoguvacine and benzodiazepine derivatives for the treatment of tactile hypersensitivity and anxiety in autism spectrum disorders
2019
David Ginty
Targeting neuro-immune signaling to treat bacterial infections
2019
Isaac Chiu
Development of a new precision therapeutic for an important cancer target
2019
Stephen Blacklow
Development of new antiviral compounds
2019
Donald Coen
Development of AAV-mediated mini-gene therapy for Usher syndrome type 1F, a combined deafness and blindness
2019
David Corey
Development of an inexpensive at-home influenza kit and detection technology
2019
Michael Springer
Small molecule modulators of gut bacterial bile acid metabolism to treat metabolic syndrome and associated non-alcoholic fatty liver disease (NAFLD)
2019
Abigail Devlin
Computationally designed therapy targeting lysosomal function and inflammation in neurodegenerative diseases
2019
Peter Park
A novel system for rational discovery of polycystic kidney disease therapeutics
2019
Adrian Salic
Monoclonal antibody-based therapeutics for Argentine hemorrhagic fever
2020
Jonathan Abraham
Targeting apoptotic pathways for ALS, Alzheimer’s Disease and Parkinson’s Disease
2020
Bruce Bean
Development of synthetic analogs of a sleeve gastrectomy-induced metabolite as a novel therapy for type 2 diabetes and obesity
2020
Abigail Devlin
Next-generation AAV therapies for management of intractable chronic pain
2020
Michael Greenberg
Developing novel therapeutic approaches for CNS drug delivery by targeting a newly identified key regulator of the blood brain barrier
2020
Chenghua Gu
Interleukin-17 as a novel erythropoiesis stimulating agent
2020
Allon Klein
Engineered proteins for treatment of pancreatitis
2020
Pamela Silver
Multiplex editing the human genome
2020
George Church
A high-throughput platform for the non-invasive intracellular delivery of molecules for therapeutic applications
2020
Johan Paulsson
Target validation and in vivo testing of a broad-spectrum antiviral
2020
Priscilla Yang
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2020
Karen Adelman
Application of the SPLANDID antigen presentation technology to HIV-1 vaccine development
2021
James Chou
A novel biologic and therapeutic target for the treatment of diabetes
2021
Douglas Melton
Development of an inexpensive at-home influenza kit and detection technology
2021
Michael Springer
Evaluating splicing modulators for therapeutic impact in cohesin-mutant AML and MDS cells
2021
Karen Adelman
Protein therapeutics for treatment of chronic and inflammatory pain
2021
Peter Sorger
Target identification of neuroprotective kinase inhibitors for Alzheimer’s and related dementias
2021
Mark Albers
Identifying novel therapeutic targets for treating pain and chronic itch
2021
David Ginty
Structure-guided discovery of novel antibiotics inhibiting bacterial cell wall formation
2021
Maofu Liao
Small molecule modulators of bile acid metabolism to treat NAFLD/NASH
2022
Abigail Devlin
A natural beta interferon-inducing therapeutic glycolipid from the microbiome that prevents and treats severe viral infection
2022
Dennis Kasper
Gene therapy for the treatment of Wolfram Syndrome II
2022
Amy Wagers
Novel biologics for cancer therapy
2022
George Church
Studies on immunogenic lipids from the gut microbiome
2022
Jon Clardy
CNS drug delivery by identifying small molecule inhibitors of a newly identified key regulator of the blood brain barrier
2022
Chenghua Gu
Development of a novel monoclonal antibody that targets SARS-CoV-2 3a
2022
John Mekalanos
Small molecule drugs for advanced cancer with ecDNA amplicons
2022
Timothy Mitchison
A platform for transcriptome time-series in single cells with applications to hematopoietic stem cells
2022
Johan Paulsson
Enzyme prospecting for better diagnostics
2022
Michael Springer
Antibody-based therapeutics against Nipah virus
2023
Jonathan Abraham
Brain-penetrant kinase inhibitors targeting Alzheimer's and related dementias
2023
Mark Albers
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